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journal of men's health
Volume 6, Issue 3
, Pages 169-176
, September 2009
Testosterone in men's health: a new role for an old hormone
References
- . Is metabolic syndrome the main threat to human health in the twenty-first century?. Arterioscler Thromb Vasc Biol. 2007;27:2275
- Metabolic syndrome and coronary heart disease risk in a population-based study of middle-aged men from France and Northern Ireland. Diabetes Metab. 2006;32:475–479
- . Frequency of the metabolic syndrome in type 2 diabetic subjects attending the diabetes clinic of a tertiary care hospital. J Pak Med Assoc. 2007;57:239–242
- Aging, androgens, and the metabolic syndrome in a longitudinal study of aging. J Clin Endocrinol Metab. 2007;92:3568–3572
- . Endogenous sex hormones and metabolic syndrome in aging men. J Clin Endocrinol Metab. 2005;90:2618–2623
- . Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men. J Clin Endocrinol Metab. 2006;91:843–850
- . Erectile dysfunction as a predictor of the metabolic syndrome in aging men: results from the Massachusetts Male Aging Study. J Urol. 2006;176:222–226
- . Evolving issues in male hypogonadism: evaluation, management, and related comorbidities. Clin J Med. 2007;74:S38–S46
- . Testosterone and aging: what we have learned since the Institute of Medicine and what lies ahead. Int J Clin Prac. 2007;61:622–632
- Contribution of age and declining androgen levels to features of the metabolic syndrome in men. Metabolism. 2005;54:1034–1040
- The metabolic syndrome and smoking in relation to hypogonadism in middle-aged men: a prospective cohort study. J Clin Endocrinol Metab. 2005;90:712–719
- . The age related decrease in testosterone is significantly exacerbated in obese men with the metabolic syndrome. What are the implications for the relatively high incidence of erectile dysfunction observed in these men?. J Urol. 2006;176:1524–1528
- Sex hormones, inflammation and the metabolic syndrome: a population-based study. Eur J Endocrinol. 2003;149:601–608
- Effects of acute hyperinsulinemia on testosterone serum concentrations in adult obese and normal-weight men. Metabolism. 1997;46:526–529
- . Epidemiology: testosterone and the metabolic syndrome. Int J Impot Res. 2007;19:124–128
- . Relationship between BMI, total testosterone, sex hormone-binding-globulin, leptin, insulin and insulin resistance in obese men. Arch Androl. 2006;52:355–361
- . Waist circumference and testosterone levels in community dwelling men. The Tromso Study. Eur J Epidemiol. 2004;19:657–663
- Leptin and androgens in male obesity: evidence for leptin contribution to reduced androgen levels. J Clin Endocrinol Metab. 1999;84:3673–3680
- . A 5 year follow-up study of disease incidence in men with an abnormal hormone pattern. J Intern Med. 2003;254:386–390
- . Androgen deficiency, diabetes and the metabolic syndrome in men. Curr Opin Endocrinol Diabetes Obes. 2007;14:226–234
- Influence of androgen suppression therapy for prostate cancer on the frequency and timing of fatal myocardial infarction. J Clin Oncol. 2007;25:2420–2425
- Metabolic syndrome in men with prostate cancer undergoing long-term androgen-deprivation therapy. J Clin Oncol. 2006;24:3979–3983
- . Low bone density and high percentage of body fat among men who were treated with androgen deprivation therapy for prostate carcinoma. Cancer. 2002;95:2136–2144
- Changes in body composition during androgen deprivation therapy for prostate cancer. J Clin Endocrinol Metab. 2002;87:599–603
- . Insulin sensitivity during combined androgen blockade for prostate cancer. J Clin Endocrinol Metab. 2006;91:1305–1308
- . Acute sex steroid withdrawal reduces insulin sensitivity in healthy men with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2007;92:4254–4259
- . Insulin resistance: link to the components of the metabolic syndrome and biomarkers of endothelial dysfunction in youth. Diabetes Care. 2007;30:2091–2097
- . Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism. J Clin Endocrinol Metab. 1996;81:4358–4365
- . Effects of testosterone supplementation in the aging male. J Clin Endocrinol Metab. 1992;75:1092–1098
- . Three-year follow-up of androgen treatment in hypogonadal men: preliminary report with testosterone gel. Aging Male. 2003;6:207–211
- Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men. J Clin Endocrinol Metab. 2004;89:2085–2098
- The effects of testosterone treatment on body composition and metabolism in middle-aged obese men. Int J Obes Relat Metab Disord. 1992;16:991–997
- . Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency. Aging Male. 2003;6:1–7
- . Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes. Eur J Endocrinol. 2006;154:899–906
- Increasing trends in incidence of overweight and obesity over 5 decades. Am J Med. 2007;120:242–250
- . Facing the diabetes epidemic – mandatory reporting of glycosylated hemoglobin values in New York City. N Engl J Med. 2006;354:545–548
- . Prevalence of the metabolic syndrome among US adolescents using the definition from the international diabetes federation. Diabetes Care. 2008;31:587–589
- . Leptin concentrations, sex hormones, and cortisol in nondiabetic men. J Clin Endocrinol Metab. 1997;82:1807–1809
- . Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study. Diabetes Care. 2000;23:490–494
- . Rancho Bernardo Study. Endogenous sex hormones and the development of type 2 diabetes in older men and women; the Rancho Bernardo study. Diabetes Care. 2002;25:55–60
- . Diabetes mellitus is associated with subnormal serum levels of free testosterone in men. BJU Int. 2005;96:867–870
- . Low serum testosterone and mortality in male veterans. Arch Intern Med. 2006;166:1660–1665
- Androgens and diabetes in men. Diabetes Care. 2007;30:234–238
- . Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA. 2006;295:1288–1299
- Association between plasma total testosterone and cardiovascular risk factors in healthy adult men: The Telecom Study. J Clin Endocrinol Metab. 1997;82:682–685
- Increasing insulin resistance is associated with a decrease in Leydig cell testosterone secretion in men. J Clin Endocrinol Metab. 2005;90:2636–2641
- Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men. Diabetes Care. 2005;28:1636–1642
- . Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen-deprivation therapy. Cancer. 2006;106:581–588
- . Association between androgen-deprivation therapy and incidence of diabetes among males with prostate cancer. Urology. 2007;70:1104–1108
- . Effects of androgen deprivation on glycaemic control and on cardiovascular biochemical risk factors in men with advanced prostate cancer with diabetes. Aging Male. 2007;10:189–196
- . Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes. J Clin Endocrinol Metab. 2004;89:5462–5468
- . Clinical and biochemical assessment of hypogonadism in men with type 2 diabetes. Diabetes Care. 2007;30:911–917
- Effect of obesity and body fat distribution on sex hormones and insulin in men. Metabolism. 1991;40:101–104
- Testosterone replacement therapy restores normal ghrelin in hypogonadal men. J Clin Endocrinol Metab. 2003;88:4139–4143
- . Effect of testosterone on insulin sensitivity in men with idiopathic hypogonadotropic hypogonaidsm. Endocr Pract. 2007;13:629–635
- . Sertoli cell function in diabetic, insulin-treated diabetic, and semi-starved rats. Diabetes. 1983;32:112–116
- Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J Clin Invest. 1997;100:808–813
- Circulating inflammatory cytokine expression in men with prostate cancer undergoing androgen deprivation therapy. J Androl. 2006;27:725–728
- Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) study. Arch Intern Med. 2007;167:2249–2254
- Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) Prospective Population Study. Circulation. 2007;116:2694–2701
- Low serum testosterone increases mortality risk among male dialysis patients. J Am Soc Nephrol. 2009;20(3):613–620
- . Low serum testosterone and mortality in older men. J Clin Endocrinol Metab. 2008;93:68–75
- . Androgen deprivation therapy, insulin resistance, and cardiovascular mortality: an inconvenient truth. J Androl. 2008;29:534–539
- . Cortisol, testosterone, and coronary heart disease prospective evidence from the Caperhill Study. Circulation. 2005;112:332–340
- . Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study. J Clin Endocrinol Metab. 2002;87:3632–3639
- . The association of hypotestosteronemia with coronary artery disease in men. Arterioscler Thromb. 1994;14:701–706
- Evaluation of sex hormone levels and some metabolic factors in men with coronary atherosclerosis. Aging Male. 2004;7:197–204
- Endogenous testosterone and serum lipids in middle-aged men. Atherosclerosis. 2008;197:688–693
- . The dark side of testosterone deficiency: I. metabolic syndrome and erectile dysfunction. J Androl. 2009;30:10–22
- . The dark side of testosterone deficiency: II. Type 2 diabetes and insulin resistance. J Androl. 2009;30:23–32
- Traish AM, Saad F, Guay AT. The dark side of testosterone deficiency: III. Cardiovascular disease. J Androl 2009 Apr 2.[Epub ahead of print].
- The effects of induced hypogonadism on arterial stiffness, body composition, and metabolic parameters in males with prostate cancer. J Clin Endocrinol Metab. 2001;86:4261–4267
- . Androgen receptor gene CAG repeat length and body mass index modulate the safety of long-term intramuscular testosterone undecanoate therapy in hypogonadal men. J Clin Endocrinol Metab. 2007;92:3844–3853
- . Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer. J Clin Oncol. 2006;24:4448–4456
- . Testosterone suppression in men with prostate cancer leads to an increase in arterial stiffness and hyperinsulinaemia. Clin Sci. 2003;104:195–201
- Androgen treatment of abdominally obese men. Obesity Res. 1993;1:245–251
- Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serium T. J Clin Endocrinol Metab. 2005;90:1502–1510
- Heufelder AE, Saad F, Bunck MC, Gooren L. 52-Week treatment with diet and exercise plus transdermal testosterone reverses the metabolic syndrome and improves glycemic control in men with newly diagnosed type 2 diabetes and subnormal plasma testosterone. J. Andrology 2009; in press.
- Changes in aortic endothelium ultrastructure in male rats following castration, replacement with testosterone and administration of 5-alpha-reductase inhibitor. Asian J Androl. 2007;9:843–847
- Low testosterone level is an independent determinant of endothelial dysfunction in men. Hypertens Res. 2007;30:1029–1034
- Reduced number of circulating endothelial progenitor cells in hypogonadal men. J Clin Endocrin Metab. 2006;91:4599–4602
- Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life. Heart. 2004;90:871–876
- . Testosterone therapy in men with moderate severity heart failure: a double-blind randomized placebo controlled trial. Eur Heart J. 2006;27:57–64
- . Effects of oral testosterone treatment on myocardial perfusion and vascular function in men with low plasma testosterone and coronary heart disease. Am J Cardiol. 2008;101:618–624
- Increased carotid atherosclerosis in andropausal middle-aged men. J Am Coll Cardiol. 2005;45:1603–1608
- . Free testosterone plasma levels are negatively associated with the intima-media thickness of the common carotid artery in overweight and obese glucose-tolerant young adult men. Int J Obes. 2003;27:803–807
- High levels of circulating testosterone are not associated with increased prostate cancer risk: a pooled prospective study. Int J Cancer. 2004;108:418–424
- Serum androgens and prostate cancer among 643 cases and 643 controls in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer. 2007;121:1331–1338
- . Endogenous Hormones, Prostate Cancer Collaborative Group. Endogenous sex hormones and prostate cancer: a collaborative analysis of 18 prospective studies. J Natl Cancer Inst. 2008;100:170–183
- . The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. J Clin Endocrinol Metab. 2004;89:3313–3318
- . Relationship of sex hormones to lipids and lipoproteins in nondiabetic men. J Clin Endocrinol Metab. 1993;77:1610–1615
- . Acute haemodynamic effects of testosterone in men with chronic heart failure. Eur Heart J. 2003;24:909–915
- . Longitudinal relation between endogenous testosterone and cardiovascular disease risk factors in middle-aged men: a 13 year follow-up of former multiple risk factor intervention trial participants. Am J Epidemiol. 1997;146:609–617
- . Cardiovascular risk factors in men: the role of gonadal steroids and sex hormone-binding globulin. Metabolism. 2001;50:882–888
- . Sex hormones and hypertension. Cardiovasc Res. 2002;53:688–708
- . Hypogonadism and metabolic syndrome: implications for testosterone therapy. J Urol. 2005;174:827–834
- Testosterone and cardiovascular risk in men: a systematic review and meta-analysis of randomized placebo-controlled trials. Mayo Clin Proc. 2007;82:29–39
PII: S1875-6867(09)00074-8
doi: 10.1016/j.jomh.2009.06.005
© 2009 WPMH GmbH. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
journal of men's health
Volume 6, Issue 3
, Pages 169-176
, September 2009
