journal of men's health
Volume 5, Issue 3 , Pages 239-244 , September 2008

Lower leptin concentration in Type 2 diabetic men

  • Chung-Hua Hsu, MD, PhD

      Affiliations

    • Community Medicine Research Center and Institute of Public Health, National Yang-Ming University, Taipei, Taiwan and Branch of Chinese Medicine, Taipei city Hospital, Taipei, Taiwan
  • ,
  • Su-Ching Lin, MD

      Affiliations

    • Department of Endocrinology, Taipei Hospital, Taipei County, Taiwan
  • ,
  • Kung-Chang Hwang, MD

      Affiliations

    • Department of Pediatrics, Taipei Hospital, Taipei County, Taiwan
  • ,
  • Ling-Na Shih, MD

      Affiliations

    • Department of Internal Medicine, Taipei Hospital, Taipei County, Taiwan
  • ,
  • Ying-Li Liao, MD

      Affiliations

    • Departments of Endocrinology and Health, Taipei Hospital, 127 Su-Yuan Road, Hsih-Chuang City, Taipei County, Taiwan
    • Corresponding Author InformationCorresponding author.

Received 20 November 2007 ,Accepted 18 March 2008.

References 

  1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologus. Nature. 1994;372:425–432
  2. Muoio DM, Dohn GL, Fiedorek FT, Tapscott EB, Coleman RA. Leptin directly alters lipid partitioning in skeletal muscle. Diabetes. 1997;46:1360–1363
  3. Caro CJ, Sinha MK, Kolaczynski JW, Zhang PL, Considine RV. Leptin: the tale of an obesity gene. Diabetes. 1996;45:1455–1462
  4. Chu NF, Spiegelman D, Rifai N, Hotamisligil GS, Rimm EB. Glycemic status and soluble tumor necrosis factor receptor levels in relation to plasma leptin concentrations among normal-weight and overweight US men. Int J Obes Relat Metab Disord. 2000;24:1085–1092
  5. Segal KR, Landt M, Klein S. Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men. Diabetes. 1996;45:988–991
  6. de Courten M, Zimmet P, Hodge A, Collins V, Nicolson M, Staten M, et al. Hyperleptinaemia: the missing link in the metabolic syndrome?. Diabet Med. 1997;14:200–208
  7. Zimmet PZ, Collins VR, de Courten M, Hodge AM, Collier GR, Dowse GK, et al. Is there a relationship between leptin sensitivity independent of obesity? A population-based study in the Indian Ocean nation of Mauritius. Mauritius NCD Study Group. Int J Obes Relat Metab Disord. 1998;22:171–177
  8. Van Dielen FM, van’t Veer C, Schols AM, Soeters PB, Buurman WA, Greve JW. Increased leptin concentrations correlate with increased concentrations of inflammatory markers in morbidly obese individuals. Int J Obes Relat Metab Disord. 2001;25:1759–1766
  9. Bernd FS, Achim P, Werner K, Jurgen B, Anderas P. Influence of sex differences in subcutaneous fat mass on serum leptin concentrations. Diabetic Care. 1998;21:1204–1205
  10. Marshall JA, Grunwald GK, Donahoo WT, Scarbro S, Shetterly SM. Percent body fat and lean mass explain the gender difference in leptin: analysis and interpretation of leptin in Hispanic and Non-Hispanic white adults. Obesity Res. 2000;8:543–552
  11. Orel M, Lichnovská R, Gwozdziewiczová S, Zlamalová N, Klementa I, Merkunová A, et al. Gender differences in tumor necrosis factor and leptin secretion from subcutaneous and visceral fat tissue. Physiol Res. 2004;53:501–505
  12. Roemmich JN, Clark PA, Berr SS, Mai V, Mantzoros CS, Flier JS, et al. Gender differences in leptin levels during puberty are related to the subcutaneous fat depot and sex steroids. Am J Physiol. 1998;275:E543–E551
  13. Menendez C, Baldelli R, Lage M, Casabiell X, Pinero V, Solar J, et al. The in vitro secretion of human leptin is gender-dependent but independent of the body mass index of the donors. Eur J Endocrinol. 2000;143:711–714
  14. Linio J, Negrao AB, Mantzoros C, Kaklamani V, Wong ML, Bongiorno PB, et al. Sex differences in circulating human leptin pulse amplitude: clinical implications. J Clin Endocrinol Metab. 1998;83:4140–4147
  15. Shimizu H, Shimomura Y, Tsuchiya T, Kobayashi I, Sato N, Mori M. Troglitazone reduces plasma leptin concentration but increases hunger in NIDDM patients. Diabetes Care. 1998;21:1470–1474
  16. Ciaraldi TP, Kong AP, Chu NV, Kim DD, Baxi S, Loviscach M, et al. Regulation of glucose transport and insulin signaling by troglitazone or metformin in adipose tissue of type 2 diabetic subjects. Diabetes. 2002;51:30–36
  17. Erdmann J, Lippl F, Wagenpfeil S, Schusdziarra V. Differential association of basal and postprandial plasma ghelin with leptin, insulin and type 2 diabetes. Diabetes. 2005;54:1371–1378
  18. McGregor GP, Desaga JF, Ehlenz K, Fischer A, Heese F, Hegele A, et al. Leptin concentrations in diabetic and nondiabetic Mexican–Americans. Diabetes. 1996;45:822–824
  19. Reilly MP, Iqbal N, Schutta M, Wolfe ML, Scally M, Localio AR, et al. Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes. J Clin Endocrinol Metab. 2004;89:3872–3878
  20. Tatti P, Masselli L, Buonanno A, Di Mauro P, Strollo F. Leptin levels in diabetic and nondiabetic subjects. Endocrine. 2001;15(3):305–308
  21. Garcia-Mayor RV, Andrade MA, Rios M, Lage M, Diequez C, Casaneueva FF. Serum leptin level in normal children: relationship to age, gender, body mass, index, pituitary-gonadal hormones and pubertal stage. J Clin Endocrinol Metab. 1997;82:2849–2855
  22. Matsuda J, Yokota I, Iida M. Serum leptin concentration in cord blood: relationship to birth weight and gender. J Clin Endocrinol Metab. 1997;82:1642–1644
  23. Tome MA, Lage M, Camina JP, Garcia MR, Diequez C, Casanueva FF. Sex-based differences in serum leptin concentrations from umbilical cord blood at delivery. Eur J Endocrinol. 1997;137:655–658
  24. Wabitsch M, Blum WF, Muche R, Braun M, Hube F, Rascher W, et al. Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J Clin Invest. 1997;100:808–813

PII: S1875-6867(08)00146-2

doi: 10.1016/j.jomh.2008.03.017

journal of men's health
Volume 5, Issue 3 , Pages 239-244 , September 2008